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BMAC & MFAT: Cellular Orthobiologics

BMAC Explained: Using Your Own Bone Marrow for Joint Pain, and What the Evidence Shows

Systematic Review / Meta-Analysis
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Dr. Paul Tortland, DO, Dual-Board Certified in Sports Medicine & Regenerative Medicine
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BMAC Explained: Using Your Own Bone Marrow for Joint Pain, and What the Evidence Shows
Written and Medically Reviewed by Dr. Paul Tortland, DO, FAOASM, CAQSM, RMSK, Dual-Board Certified in Sports Medicine & Regenerative Medicine
·
October 18, 2026
What You Need to Know

Bone marrow aspirate concentrate (BMAC) is a same-day procedure that uses a patient's own bone marrow, drawn from the back of the pelvis, concentrated, and injected under image guidance. Many patients with knee osteoarthritis report less pain and better function, but BMAC does not regrow cartilage and has not been proven superior to PRP, other cell-based injections, or corticosteroid in well-designed trials.

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Direct answer: Bone marrow aspirate concentrate (BMAC) is a same-day, in-office procedure that uses a small amount of your own bone marrow, drawn from the back of the pelvis, concentrated, and injected under image guidance into an arthritic joint or damaged tissue. Many patients with knee osteoarthritis report less pain and better function afterward. However, BMAC has not been shown to regrow cartilage, and the best-designed trials have not shown it to outperform other injections.

What BMAC Is, and Why "Stem Cell" Is Only Part of the Story

Bone marrow contains a mix of cells: a small population of mesenchymal stromal cells (often called "stem cells"), along with platelets, white blood cells, and signaling proteins. BMAC concentrates that whole mix into a small injectable volume. Only a small fraction of the concentrated cells are mesenchymal stromal cells, which is why many physicians describe BMAC as a cellular orthobiologic rather than a "stem cell treatment."

Current thinking is that most of BMAC's effect comes from signaling. The concentrate influences inflammation and the chemical environment inside a joint. It does not work by new cells turning into new cartilage. That distinction matters for setting realistic expectations.

Because the cells come from you and are processed and returned during the same visit, BMAC belongs to a different category from the commercial donor-tissue products sold as "stem cells." Our article on real vs. commercial stem cell products explains that difference in detail.

How the Procedure Works

For arthritis, a cellular procedure is often followed by a PRP procedure roughly 4 to 6 weeks later as part of the overall treatment plan.

Who May Be a Candidate

BMAC is most often considered for:

In our practice, patients referred for BMAC often have already tried a round of PRP or a corticosteroid injection that gave some relief but not enough to last, which is a pattern we see regularly. BMAC is generally a poor fit for end-stage, bone-on-bone arthritis with deformity, joints with mechanical instability, and completely torn or retracted tendons. Some medical conditions and medications also affect whether a marrow harvest is appropriate; these are reviewed during the evaluation.

What the Current Evidence Shows

The research on BMAC is promising for symptom relief but humbling on the question of whether it beats other options:

Taken together, the honest summary is this: BMAC appears safe and can meaningfully reduce pain for many patients, but it has not been proven better than simpler or less expensive injections, and it does not rebuild cartilage.

When Non-Surgical Care May Be Appropriate

For patients with mild to moderate arthritis whose main goals are less pain, better function, and staying active, a non-surgical plan is often a reasonable first path. That plan usually combines exercise-based rehabilitation, activity modification, and, when the evaluation supports it, an orthobiologic such as PRP or BMAC. The choice between options depends on the diagnosis, the imaging findings, prior treatment response, and cost, and it is made together with the patient.

When Surgery May Be More Appropriate

Surgery is usually the better answer for advanced, bone-on-bone arthritis with deformity, for joints that are mechanically unstable, for large or retracted tendon tears, and for patients whose pain and loss of function remain severe despite a genuine trial of non-surgical care. In those situations, Dr. Tortland says so directly and refers patients to trusted orthopedic surgeons.

What BMAC Does Not Do

Dr. Tortland's Perspective

My approach is the same for every patient: validate that the pain is real, investigate the actual cause with a careful exam and diagnostic ultrasound, and only then talk about regenerating. BMAC is a tool I use for the right patient, often someone with moderate arthritis who wants to stay active and has not gotten enough from simpler care. I also tell patients plainly what the research shows, including the trials where BMAC did not beat other injections. I would rather a patient make this decision with accurate expectations, and when surgery is the better path, I will say so.

Related Questions

Next Step

If you are considering BMAC, start with an evaluation, not a procedure. Learn more on the Cellular Orthobiologics page, or schedule a consultation for an unrushed exam, a live ultrasound assessment, and a clear discussion of every option, surgical and non-surgical.

Comparison at a Glance

TreatmentMechanismDurationBest Candidate Stage
PRP (platelet-rich plasma)Concentrated platelets and signaling proteins influence inflammation and tissue repairRelief commonly develops over weeks and may last monthsCondition-specific indications where PRP has supporting evidence
Standardized kit-based PRPUses a commercial processing system with a defined but variable platelet concentration rangeVariable by preparation and patientPatients considering PRP when the exact final concentration may not be measured
Patient-specific measured PRPFinal platelet concentration is measured and compared with baseline before injectionVariable; treatment effects are assessed over weeks to monthsPatients for whom preparation characteristics and dosing transparency are important

Frequently Asked Questions

Is BMAC the same as stem cell therapy?

Partly. BMAC contains a small population of mesenchymal stromal cells, but most of the concentrate is other cells and signaling proteins. Its benefit appears to come mainly from signaling that calms inflammation, not from cells turning into new cartilage.

Does the bone marrow harvest hurt?

The harvest site on the back of the pelvis is numbed with local anesthetic first. Most patients describe pressure and a brief deep ache rather than sharp pain, with some soreness at the site for a few days.

How long does a BMAC visit take?

Plan on 2 to 3 hours for the entire visit, including the harvest, on-site processing, and the image-guided injection.

Is BMAC better than PRP?

Not proven. Systematic reviews and a large randomized trial have not shown BMAC to outperform PRP or other injections. It may be considered when PRP alone has not helped enough, but that decision is individual.

Is BMAC regulated by the FDA?

Yes. When the cells are your own, minimally manipulated, and returned during the same procedure, BMAC falls under the FDA's framework in 21 CFR Part 1271, which is different from the approval pathway required for donor-derived "stem cell" products.

Does insurance cover BMAC?

Most orthobiologic procedures are not covered by U.S. insurers. Patients receive a Good Faith Estimate in advance and detailed claim forms they can submit for possible reimbursement.

How painful is the bone marrow aspiration for BMAC?

The harvest is typically done under local anesthetic, and most patients describe pressure or brief discomfort rather than sharp pain during the aspiration itself, with some soreness at the harvest site afterward.

How many BMAC treatments are typically needed over time?

Many patients receive a single BMAC treatment per joint and are reassessed based on response; some may be considered for a repeat treatment later if symptoms recur or evidence supports it for their specific condition.

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Portrait of Dr. Paul Tortland, DO

Dual-Board-Certified · Fellowship-Trained · Specialist in Regenerative Orthopedics

About Paul D. Tortland, DO

Dr. Paul Tortland was the first physician in southern New England to offer PRP and BMAC + MFAT stem cell treatments for Orthopedic injuries, treating patients since 2007 with a customized, ultrasound-guided approach and measured, high-concentration PRP preparations at his Glastonbury, CT practice.

References & Further Reading

View 4 medical references and further reading
  1. Keeling LE, et al. Bone Marrow Aspirate Concentrate for the Treatment of Knee Osteoarthritis: A Systematic Review. Am J Sports Med. 2022;50(8):2315-2323. doi:10.1177/03635465211018837
  2. Shapiro SA, et al. A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis. Am J Sports Med. 2017;45(1):82-90. doi:10.1177/0363546516662455
  3. Mautner K, et al. Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial. Nat Med. 2023;29(12):3120-3126. doi:10.1038/s41591-023-02632-w
  4. Migliorini F, et al. Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. Br Med Bull. 2025;153(1). doi:10.1093/bmb/ldae016