Cellular orthobiologics (BMAC and MFAT)
Also known as stem cell therapy or regenerative medicine, cellular orthobiologics uses your own cells when platelets alone aren't enough signal for a degenerated joint: treatment moves to Bone Marrow-derived Stem Cell and Adipose / Fat-derived Stem Cell treatments, harvested, concentrated, and injected the same day, all under ultrasound and/or fluoroscopic guidance. Every cell comes from you, never a donor, and never an off-the-shelf product.
Quick answer
Cellular orthobiologics, BMAC (bone marrow aspirate concentrate) and MFAT (microfragmented adipose tissue), are autologous stem cell treatments using cells taken from your own body: bone marrow concentrate from the pelvis, or adipose tissue from a small fat harvest. They are injected into a degenerated joint or tendon under ultrasound or fluoroscopic guidance. They deliver progenitor cells plus signaling proteins, a stronger biologic stimulus than PRP, and are used for moderate to advanced osteoarthritis, severe partial tears, and stubborn tendon disease.
Time in office
2 to 3 hours
Anesthesia
Local, optional light sedation
Typical course
Usually one treatment
Return to desk work
1 to 3 days
First results
Weeks 6 to 16
Cell source
Your marrow or your fat
Donor tissue used
Never
Insurance
Not covered in the US
Definition
They are autologous cell-based treatments: your own marrow or adipose tissue, concentrated and returned to the injured joint in a single visit.
Bone marrow aspirate concentrate (BMAC) is drawn from the iliac crest and concentrated in office. It carries progenitor cells, platelets, and a dense mix of signaling proteins. Adipose-derived treatment (MFAT) uses a small, minimally invasive fat harvest, yielding a cell-rich graft that also provides mechanical cushioning inside the joint.
Both are performed and injected the same day, with nothing cultured, expanded, or shipped to a lab. Nothing from an outside donor or commercial product is used: no amniotic, umbilical, or "off-the-shelf" product sold as stem cells. Independent laboratory testing of these commercial products has generally not found viable stem cells after processing.
Indications
Generally reserved for joints and tendons where degeneration is too advanced for platelets alone.
Step by step
01
Dynamic ultrasound plus review of your imaging determines whether the joint has enough remaining structure to respond, and which cell source suits your case.
02
Marrow is aspirated from the iliac crest, or a small volume of fat is harvested through a minimally invasive technique. The site is thoroughly numbed first; this step takes 15 to 25 minutes.
03
The sample is concentrated in office while you rest. Nothing is cultured, expanded, frozen or sent to an outside laboratory.
04
The concentrate is placed into the joint and, where indicated, into surrounding ligament and tendon attachments under live ultrasound.
05
You leave with a staged plan: relative rest for several days, then progressive loading. Crutches are occasionally used for large weight-bearing joints.
06
Review at six weeks and again at three to four months with repeat ultrasound, comparing the joint against its baseline images.
Candidacy
Comparison
HONEST LIMITS
Bone marrow aspirate concentrate and microfragmented fat don't regrow cartilage, reverse end-stage arthritis, or guarantee you'll avoid surgery. Candidacy is judged on what live ultrasound actually shows, not hope or marketing claims. If imaging shows a problem these treatments aren't a good fit for, we'll say so and discuss surgical referral or other options directly.
See how we help you honestly weigh surgery vs. non-surgical care →Frequently asked
Yes, in the accurate sense: it uses your own bone marrow or fat, which contain living progenitor (stem) cells along with many other healing components. It is not an FDA-approved or FDA-cleared drug product: it is a same-day procedure performed within FDA rules (see the FDA question below). Dr. Tortland describes these procedures by what they actually are: autologous, same-day, minimally manipulated cell concentrates, not a vague "stem cell" brand name.
From you, on the day of your procedure: either your bone marrow or your own fat. No embryonic, donor, amniotic, or umbilical tissue is used. Commercial "off-the-shelf" products marketed as stem cells have generally not been shown to contain living stem cells after processing, so a clinic offering one of those products is not offering the same treatment as your own cells.
Generally, yes, when it's your own tissue used the same day. There's no rejection risk, and the most common side effects are soreness at the harvest and injection sites with a temporary flare; infection and bleeding are rare. The real safety concern is products sold as "stem cells" that come from a donor: those aren't FDA-approved for orthopedic use, and the FDA has publicly warned patients about them. Dr. Tortland uses only your own tissue, processed in-office under FDA guidelines, and screens for infection or blood-thinner use before every procedure.
No, and be cautious of any provider who tells you otherwise. These cells mainly work by signaling: releasing growth factors and anti-inflammatory molecules that calm the joint and support healing, not by turning into new cartilage. The scientist who named mesenchymal stem cells now calls them "medicinal signaling cells" for exactly this reason. The realistic goal is less pain, better function, and a slower path to surgery, not cartilage regrowth.
More than PRP, because of the extra harvest time, processing, and materials involved, but there's no flat number until your evaluation. Exact pricing is quoted in writing once your target area and the volume needed are known, and nothing is charged before you have that written plan.
Most patients tolerate it well. Both harvest sites are fully numbed first, so you'll feel pressure or pulling rather than sharp pain. For BMAC, marrow is drawn from the back of the pelvis under ultrasound guidance in under 20 minutes. For MFAT, a small amount of fat is taken from the abdomen or flank using a mini-liposuction technique, in about 30 minutes, with no stitches or general anesthesia. Light sedation is available if you'd like it.
Not right away: this isn't like a cortisone shot. BMAC and MFAT work by shifting the healing environment in the joint, so meaningful change usually starts between weeks six and sixteen, and can keep improving for up to a year. More advanced joints tend to respond more slowly, and results depend on an accurate diagnosis and following through on rehab, which is why every plan starts with an ultrasound-guided evaluation.
Usually, yes, with one common exception: for arthritis, the plan often adds a PRP injection 4 to 6 weeks after the cellular treatment to build on the result. Beyond that, a second cellular treatment is only considered if the first gave partial improvement and follow-up ultrasound shows there's more to gain.
Yes, it's performed entirely within FDA rules: it just isn't "FDA-approved" in the drug-product sense, because no same-day autologous procedure like this is regulated that way. BMAC and MFAT here follow FDA 21 CFR Part 1271 and Section 361 of the Public Health Service Act: the tissue is your own, minimally manipulated with nothing added, and processed and re-implanted in one procedure. If a clinic claims outright "FDA approval" for a stem cell treatment, or uses cultured or donor-derived products, that's a red flag.
Sources
01
Mulvaney SW, Tortland PD, Shiple B, Curtis K. Regenerative medicine options for chronic musculoskeletal conditions: a review of the literature. Endurance and Sports Medicine. 2018.
02
Centeno CJ, et al. Symptomatic knee osteoarthritis treated with autologous bone marrow concentrate: registry outcomes at multi-year follow-up.
03
Hernigou P, et al. Bone marrow aspirate concentrate for osteonecrosis and osteoarthritis: cell dose and clinical outcome relationships.
04
Kim GB, et al. Adipose-derived cell therapy for knee osteoarthritis: systematic review of clinical outcomes and safety.
05
American Academy of Orthopaedic Surgeons. Position statement on the use of orthobiologics in musculoskeletal care.
06
OrthoBiologics Ethics Consortium. Consensus principles for ethical research, marketing and clinical use of orthobiologics.
Cellular treatment is only worth doing when ultrasound and imaging show the joint has something to work with. One evaluation gives you that answer.